abstract：BACKGROUND:Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to detect ex...

journal_title：Journal of biomedical science

authors： Cheng YR,Jiang BY,Chen CC

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulation remains unclear. However, Ca2+ activates the L-Type voltage sensitive calcium channel β-3 sub...

journal_title：Journal of biomedical science

authors： Neuwirth LS,Phillips GR,El Idrissi A

更新日期：2018-05-24 00:00:00

abstract：:Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential the...

journal_title：Journal of biomedical science

authors： Khan S,Mahmood MS,Rahman SU,Zafar H,Habibullah S,Khan Z,Ahmad A

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND:LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. METHODS:The overexpression and knockdown models of Gas5 and miR-21 in cells and animals were cons...

journal_title：Journal of biomedical science

authors： Liu X,She Y,Wu H,Zhong D,Zhang J

更新日期：2018-02-28 00:00:00

abstract：BACKGROUND:Chemotherapy and targeted therapies have made important strides in cancer treatment yet they often fail and new therapies are still needed. Here, we employed a phenotypic screen to identify and analyze the mechanism of action of novel small molecules that interfere with critical pathways involved in tumor ce...

journal_title：Journal of biomedical science

authors： Ghosh SK,Ganta A,Spanjaard RA

更新日期：2018-02-08 00:00:00

abstract：:The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current app...

journal_title：Journal of biomedical science

authors： Zhou Y

更新日期：2017-10-18 00:00:00

abstract：:The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. At the MAM, the Sig-1R is known to play a role in regulating the Ca2+ signaling between ER and mitochondr...

journal_title：Journal of biomedical science

authors： Weng TY,Tsai SA,Su TP

更新日期：2017-09-16 00:00:00

abstract：:Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence. Decrease in the capacity of oxidative metabolism and mitochondrial dysfunction are a major contributor to the...

journal_title：Journal of biomedical science

authors： Wang CH,Wei YH

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except for its N-terminus (AC6-N, aa 1-86). Activation of AC6, rather than AC5, produces cardioprotective ...

journal_title：Journal of biomedical science

authors： Wu YS,Chen CC,Chien CL,Lai HL,Jiang ST,Chen YC,Lai LP,Hsiao WF,Chen WP,Chern Y

更新日期：2017-09-04 00:00:00

abstract：BACKGROUND:To mimic systemic inflammation in humans, different animal models have been developed. Since these models are still discussed controversially, we aimed to comparatively evaluate the most widely used models with respect to the systemic effects, the influence on organ functions and to the underlying pathophysi...

journal_title：Journal of biomedical science

authors： Seemann S,Zohles F,Lupp A

更新日期：2017-08-24 00:00:00

abstract：BACKGROUND:Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further...

journal_title：Journal of biomedical science

authors： Kumar S,Rathkolb B,Sabrautzki S,Krebs S,Kemter E,Becker L,Beckers J,Bekeredjian R,Brommage R,Calzada-Wack J,Garrett L,Hölter SM,Horsch M,Klingenspor M,Klopstock T,Moreth K,Neff F,Rozman J,Fuchs H,Gailus-Durner V,H

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like recep...

journal_title：Journal of biomedical science

authors： Schwarz A,Bonaterra GA,Schwarzbach H,Kinscherf R

更新日期：2017-02-07 00:00:00

abstract：:Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being ...

journal_title：Journal of biomedical science

authors： Pak J,Lee JH,Park KS,Park M,Kang LW,Lee SH

更新日期：2017-01-31 00:00:00

abstract：BACKGROUND:Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynamics and reduce resuscitation fluid requirements after hemorrhagic shock. METHODS:Anesthetized male ...

journal_title：Journal of biomedical science

authors： Nassoiy SP,Byron KL,Majetschak M

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. METHODS AND RESULTS:Q-PCR and ...

journal_title：Journal of biomedical science

authors： Yan X,Pan B,Lv T,Liu L,Zhu J,Shen W,Huang X,Tian J

更新日期：2017-01-05 00:00:00

abstract：:The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for advanced EGFR mutation-positive non-small cell lung cancer. The third-generation (3G) EGFR-TKIs have been develop...

journal_title：Journal of biomedical science

authors： Liao BC,Lin CC,Lee JH,Yang JC

更新日期：2016-12-03 00:00:00

abstract：BACKGROUND:Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor...

journal_title：Journal of biomedical science

authors： Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY,Liou JP,Ko CY,Chang KY,Chuang JY

更新日期：2016-11-18 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. This has ope...

journal_title：Journal of biomedical science

authors： Wang LT,Ting CH,Yen ML,Liu KJ,Sytwu HK,Wu KK,Yen BL

更新日期：2016-11-04 00:00:00

abstract：:A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo ...

journal_title：Journal of biomedical science

authors： Tzeng HT,Wang YC

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and various side effects, thus a search for complementary/alternative medicines from natural sources with les...

journal_title：Journal of biomedical science

authors： Banerjee M,Chattopadhyay S,Choudhuri T,Bera R,Kumar S,Chakraborty B,Mukherjee SK

更新日期：2016-04-16 00:00:00

abstract：:In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous p...

journal_title：Journal of biomedical science

authors： Ponuwei GA

更新日期：2016-03-17 00:00:00

abstract：BACKGROUND:The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting peptide that could specifically bind to aminopeptidase N (APN), which is an NGR receptor expressed on t...

journal_title：Journal of biomedical science

authors： Li JJ,Chang SF,Liau II,Chan PC,Liu RS,Yen SH,Wang HE,Chang CA

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Homeostasis of reactive oxygen species (ROS) in the skin is regulated by antioxidant defenses. The inflammatory states of skin diseases which range from acute rashes to chronic conditions are related to the level of ROS. The involvement of superoxide dismutase (SOD) in restoring the antioxidant capacity can ...

journal_title：Journal of biomedical science

authors： Liu TP,Chen YP,Chou CM,Chiu TT,Chen CT

更新日期：2016-01-20 00:00:00

abstract：:Ischemia and reperfusion (I/R) - induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial infarction, ischemic stroke, cardiac arrest and trauma. An imbalance between oxygen demand and supply, within the...

journal_title：Journal of biomedical science

authors： Tasoulis MK,Douzinas EE

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Developing brain is a major target for alcohol's actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies have shown that ethanol altered the lateral ventricular neuroepithelial cell proliferation. However, t...

journal_title：Journal of biomedical science

authors： Riar AK,Narasimhan M,Rathinam ML,Henderson GI,Mahimainathan L

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptides, bis-(N-aminocaproyl-glycyl-L-lysine) hexamethylenediamide (GK-6) and bis(N-succinyl-L-glutamyl-L-...

journal_title：Journal of biomedical science

authors： Gudasheva TA,Povarnina PY,Antipova TA,Firsova YN,Konstantinopolsky MA,Seredenin SB

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated immune escape involving TGF-β management in gastric cancer (GC). However, the mechanism underlying it ...

journal_title：Journal of biomedical science

authors： Guan Z,Song B,Liu F,Sun D,Wang K,Qu H

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limited. We established a constitutive MEK2 transgenic zebrafish, Tg(krt14:MEK2S219D-GFP), to elucidate ...

journal_title：Journal of biomedical science

authors： Chou CM,Chen YC,Su S,Chen GD,Huang KY,Lien HW,Huang CJ,Cheng CH

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8(+) T cells. The existence of an atypical cytotoxic CD4(+)NKG2D(+) T cell population has also been found in patients with autoimmune dysfunctions. Nonetheless, contradictory evidence has categorized this population with a regulat...

journal_title：Journal of biomedical science

authors： Garcia-Chagollan M,Jave-Suarez LF,Haramati J,Bueno-Topete MR,Aguilar-Lemarroy A,Estrada-Chavez C,Bastidas-Ramirez BE,Pereira-Suarez AL,Del Toro-Arreola S

更新日期：2015-10-20 00:00:00

abstract：:Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a weapon of phagocytes, employed against pathogens invading the host. However, during the last decade, an understanding has emerged that ...

journal_title：Journal of biomedical science

authors： Belikov AV,Schraven B,Simeoni L

更新日期：2015-10-15 00:00:00

abstract：:Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The early prediction of severe dengue in patients without any warning signs who may lat...

journal_title：Journal of biomedical science

authors： John DV,Lin YS,Perng GC

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member expressed in lung epithelial cells. CADM1 generates a membrane-associated C-termin...

journal_title：Journal of biomedical science

authors： Hagiyama M,Yoneshige A,Inoue T,Sato Y,Mimae T,Okada M,Ito A

更新日期：2015-08-11 00:00:00

abstract：:Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagno...

journal_title：Journal of biomedical science

authors： Rosadas C,Puccioni-Sohler M

更新日期：2015-08-08 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and elevated in the regions of tissue injury and inflammatory diseases. The deleterious effects of TNF-α on fibroblasts may aggravate heart inflammation mediated through the up-regulation of adhesion molecules such as vascular cell adhesion molecu...

journal_title：Journal of biomedical science

authors： Lin CC,Pan CS,Wang CY,Liu SW,Hsiao LD,Yang CM

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Parkinson's disease is the second most common neurodegenerative disorders after Alzheimer's disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. Neuronal apoptosis and neuroinflammation are thought to be the key contributors to the neuronal degen...

journal_title：Journal of biomedical science

authors： Lin YL,Tsay HJ,Lai TH,Tzeng TT,Shiao YJ

更新日期：2015-05-28 00:00:00

abstract：BACKGROUND:Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a pre...

journal_title：Journal of biomedical science

authors： Mazzucco MB,Talarico LB,Vatansever S,Carro AC,Fascio ML,D'Accorso NB,García CC,Damonte EB

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:ESBL-producing bacteria are a clinical problem in the management of diseases caused by these pathogens. Worldwide, systemic infections with BL enzymes are evolving by mutations from classical bla genes in an intensified manner and they continue to be transferred across species. RESULTS:E.cloacae BF1417 isol...

journal_title：Journal of biomedical science

authors： Bourouis A,Ben Moussa M,Belhadj O

更新日期：2015-04-11 00:00:00

abstract：BACKGROUND:Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effective at very high doses for only palliative management of these prostate cancers. Therefore chemo-se...

journal_title：Journal of biomedical science

authors： Gara RK,Srivastava VK,Duggal S,Bagga JK,Bhatt M,Sanyal S,Mishra DP

更新日期：2015-04-01 00:00:00

abstract：BACKGROUNDS:Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplantation (BMT) from a 32/32 donor has been shown to cure an HIV-infected patient. However, the rari...

journal_title：Journal of biomedical science

authors： Manotham K,Chattong S,Setpakdee A

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaOx stone diseases are limited. Oxalate degrading bacteria might have beneficial effects on urinary ox...

journal_title：Journal of biomedical science

authors： Sasikumar P,Gomathi S,Anbazhagan K,Abhishek A,Paul E,Vasudevan V,Sasikumar S,Selvam GS

更新日期：2014-08-30 00:00:00